Wu Zi Yan Zong Wan, The Five Seed Fertility Fruits Formula

Wu Zi Yan Zong Wan

The Five Seed Fertility Fruits Formula

Wu Zi Yan Zong Wan is a Traditional Chinese Medicine often referred to as “the fertility fruits” or the “five ancestors tea pills.” This formula combines five seeds and berries that help a man’s body keep his reproductive energies from “leaking.” With his masculine powers properly directed, he is more readily able to father children. The formula also encourages stronger erections, longer lasting intercourse, and increased fertility. Let’s take a look at the five “ancestor” herbs that make up the formula.


Gou Qi Zi (also known as Fructus Lycii Chinensis and goji berry) is added to formulas as a Yin tonic. The energies of the herb assist the “holding” energies of the body.  It helps the lungs hold moisture so they are moistened. This stops dry cough. It brightens the eyes both physically and energetically. It can relieve dry eye, but it can also resolve the effects of emotional energies that make the eyes tired. And it nourishes the energies of the Kidney, to hold fluids and the reproductive force known as Jing, and the Liver, to house emotions until they can be properly processed.  It helps a man focus his raw emotional energy on what’s important.

In scientific terms, however, Gou Qi Zi has a much more specific effect on a man’s sex life. It contains compounds that help preserve dopamine-making neurons in the brain. Dopamine is the brain’s reward chemical. Maintaining the brain’s normal production of dopamine maintains a man’s normal interest in sex.[1] It also helps you feel better about your life in general. A clinical trial that involved drinking 120 ml (half a cup) of goji berry juice every day for 15 days found that it significantly “improves subjective measures of energy levels, athletic performance, sleep quality, mental acuity, calmness, feelings of health and contentment, mood, and gastrointestinal regularity compared to placebo.”[2]


Tu Si Zi (also known as Semen Cucscutae Chinensis and ) s strengthens Yang, nourishes Yin, and astringes Jing. What does that mean? Chinese dodder seed gives the body’s outward, assertive energies a boost. At the same time it helps the body hold onto energies needed for its inner workings. The combination of these effects helps the body conserve Jing, or its reproductive essence.

Tu Si Zi has many other applications. This herb contains as-yet unidentified compounds that relieve knee pain.[3] Energetically, the knees, the Kidney, and a man’s reproductive function are all interrelated. Practically, if your knees are killing you, you aren’t going to have good sex. Along with epimedium (horny goat weed), Tu Si Zi helps improve the male memory.[4] But most importantly for male fertility, laboratory studies confirm that Tu Si Zi improves sperm’s “swimming ability” and strengthens the sperm’s cell membrane against oxidative assault.[5]


Che Qian Zi (also Semen Plantaginis and psyllium seed) is a sweet, cooling herb. Its energies calm those of the Bladder, Kidney, Liver, and Lung.  It promotes

urination. This helps “dry out” diarrhea. It clears Liver Heat, the energetic effect of strong emotions that cannot be contained. This normalizes energies in the breasts and eyes. And it clears phlegm from the Lungs.  In Western medicine, psyllium seed is the most commonly prescribed source of natural fiber, used to treat both constipation and diarrhea, but it also keeps digested sugars from entering the body too quickly.

Western medicine has focused on the use of psyllium seed as a treatment for constipation and high cholesterol, so it has not investigated how the herb can support men’s reproductive health. However, there is laboratory evidence that Che Qian Zi increases the production of bile salts. The liver uses bile salts to remove excess estrogen from the body.[6] It is possible, although it’s not proven, that this ingredient helps a man’s body to eliminate estrogen-like compounds from food and polluted drinking water.


Fu Pen Zi (also known as Fructus Rubi Chingii and Chinese Raspberry Fruit) contributes energies that stabilize and bind. It is also an astringent herb. It keeps vital energies from leaking out of the body. Traditional herbalism uses it to invigorate Yang energies to reduce urinary frequency, enuresis, impotence, spermatorrhea, premature ejaculation, or wet dreams.

Modern science confirms that Fu Pen Zi is a vasodilator.[7] It supports the movement of blood into the penis for a stronger erection. It’s also a muscle relaxant.[8] It prevents muscle spasms that could occur at just the wrong time and ruin good sex.


Wu Wei Zi, literally the “fruit of five flavors (also known as Fructus Schisandrae Chinensis and schisandra fruit) is sweet, salty, sour, bitter, and pungent. Its five flavors enable it to lend its energies to all five of the energy organs of the human body, the Heart, Kidneys, Liver, Lungs, and Spleen. This herb also has five functions. It can calm, clear, and tonify the body, as well as expel “evil energies” known as Wind and break up stagnation, the physical effects of energies out of place.

Schisandra also has scientifically documented potencies. It stimulates the production of several detoxifying enzymes in the liver, including the CYP2E1 we talked about above and also CYP1A2 and CYP3A11. This helps the liver detoxify caffeine. It also helps a man’s body clear out estrogens that may have been generated by the breakdown of plastics or that come from other sources of environmental pollution.[9]

The formula Wu Zi Yan Zong Wan acting as a whole has been scientifically demonstrated to treat the effects of alcohol on the liver.[10] It acts on a specific enzyme system called CYP2E1.[11] This is the enzyme your body uses to detoxify a huge number of environmental chemicals. It’s absolutely critical for the body to detoxify benzene and aniline dyes. It is the enzyme that clears out painkillers and anesthesia. It’s also the enzyme your liver uses to detoxify alcohol.

But of more interest to most men is the fact that laboratory studies confirm that Wu Zi Yan Zong Wan makes erections stronger, specifically in males with hypertension.[12] It normalizes the production of a compound called nitric oxide (NO) in the cavernus cavernosum, the blood vessels that power the penis. It allows the penis to relax and fill with blood so it becomes erect. Although Wu Zi Yan Zong Wan is not so strong that it comes with the warning “For erections that last more than four hours, see your doctor,” it has the same action as the “little blue pill” that your doctor might prescribe for you.

How do you reconcile the Western science with the known efficacy of the formula in TCM? It’s simple, really. Wu Zi Yan Zong Wan is not a formula is not a formula for men who “have something wrong with them.” It is just a formula that removes certain physiological distractions that interfere with fertility and enjoyment of sex.

Men who have problems in the bedroom or disappointments with pregnancy don’t necessarily have problems specifically in their reproductive organs. The problem may really be the toxic effects of chemicals on the job. Or it can be the physiological effects of toxic emotional experiences. Or it can be the after effects of anesthesia from surgery or even the general stress of an infection somewhere else in the body.

Wu Zi Yan Zong Wan is given to men who function perfectly well as men, but just need some help dealing with toxic environments or toxic lifestyle. Six months of treatment with Wu Zi Yan Zong Wan will help the men who need resume their normal sexual potency as they achieve generally better health.

[1] Lin S, Ye S, Huang J, Tian Y, Xu Y, Wu M, Wang J, Wu S, Cai J. How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis? Neural Regen Res. 2013 Oct 25;8(30):2820-6. doi: 10.3969/j.issn.1673-5374.2013.30.004. PMID: 25206603.

[2] Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi. J Altern Complement Med 2008;14:403-12.

[3] Liang Y et al. Effects of traditional Chinese medicine and rehabilitation training on knee joint function after anterior cruciate ligament reconstruction in arthroscopy. Chinese Journal of Clinical Rehabilitatin. 2006;10(27):6-10.

[4] Liu, Z. Y., Yang, Y. G., and Zheng, B. [Effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(11):675-6, 646.

[5] Peng, S. J., Lu, R. K., and Yu, L. H. [Effects of semen Cuscutae, rhizoma Curculiginis, radix Morindae officinalis on human spermatozoan’s motility and membrane function in vitro]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;17(3):145-147

[6] Jenkins DJ, Kendall CW, Axelsen M, et al. Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000;11:49-56.

[7] Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.

[8] Bamford DS, Percival RC, Tothill AU. Raspberry leaf tea: a new aspect to an old problem. Br J Pharmacol 1970;40:161P-162P.

[9] Hong M, Zhang Y, Li S, Tan HY, Wang N, Mu S, Hao X, Feng Y. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae. Molecules. 2017 Sep 28;22(10). pii: E1617. doi: 10.3390/molecules22101617. PMID: 28956809.

[10] Chen ML, Tsai SH, Ip SP, Ko KM, Che CT. Long-term treatment with a “Yang-invigorating” Chinese herbal formula, Wu-Zi-Yan-Zong-Wan, reduces mortality and liver oxidative damage in chronic alcohol-intoxicated rats. Rejuvenation Res. 2010 Aug;13(4):459-67. doi: 10.1089/rej.2009.0985. PMID: 20583953.

[11] Chen ML, Ip SP, Tsai SH, Ko KM, Che CT. Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells.

J Ethnopharmacol. 2010 Mar 2;128(1):116-22. doi: 10.1016/j.jep.2009.12.036. Epub 2010 Jan 4.

PMID: 20051262.

[12] Sohn, D. W., Kim, H. Y., Kim, S. D., Lee, E. J., Kim, H. S., Kim, J. K., Hwang, S. Y., Cho, Y. H., and Kim, S. W. Elevation of intracavernous pressure and NO-cGMP activity by a new herbal formula in penile tissues of spontaneous hypertensive male rats. J.Ethnopharmacol. 11-20-2008;120(2):176-180.